On 31st May 2011, the World Health Organization confirmed that mobile phone use may represent a long-term health risk, classifying mobile phone radiation as a "carcinogenic hazard" and "possibly carcinogenic to humans" after a team of scientists reviewed peer-review studies on cell phone safety. One study of past cell phone use cited in the report showed a "40% increased risk for gliomas (brain cancer) in the highest category of heavy users (reported average: 30 minutes per day over a 10‐year period)." This is a reversal from their prior position that cancer was unlikely to be caused by cellular phones or their base stations and that reviews had found no convincing evidence for other health effects. Certain countries, including France, have warned against the use of cell phones especially by minors due to health risk uncertainties.

The effect mobile phone radiation has on human health is the subject of recent interest and study, as a result of the enormous increase in mobile phone usage throughout the world (as of June 2009, there were more than 4.3 billion users worldwide). Mobile phones use electromagnetic radiation in the microwave range, which some believe may be harmful to human health. A large body of research exists, both epidemiological and experimental, in non-human animals and in humans, of which the majority shows no definite causative relationship between exposure to mobile phones and harmful biological effects in humans. This is often paraphrased simply as the balance of evidence showing no harm to humans from mobile phones, although a significant number of individual studies do suggest such a relationship, or are inconclusive. Other digital wireless systems, such as data communication networks, produce similar radiation.

At least some recent studies have found an association between cell phone use and certain kinds of brain and salivary gland tumors. Lennart Hardell and other authors of a 2009 meta-analysis of 11 studies from peer-reviewed journals concluded that cell phone usage for at least ten years “approximately doubles the risk of being diagnosed with a brain tumor on the same ('ipsilateral') side of the head as that preferred for cell phone use.”

In addition, a mobile phone can spread infectious diseases by its frequent contact with hands. One study came to the result that pathogenic bacteria are present on approximately 40% of mobile phones belonging to patients in a hospital, and on approximately 20% of mobile phones belonging to hospital staff.